The two clubs have a long history of competing against each other in various competitions, including the EFL Championship.
Plymouth Argyle is nicknamed "The Pilgrims" and plays its home matches at Home Park, which has a capacity of over 18,000.
Oxford United is nicknamed "The U's" and plays its home matches at the Kassam Stadium, which has a capacity of over 12,000.
Plymouth Argyle has a strong rivalry with local team Exeter City, known as the Devon Derby, while Oxford United has a strong rivalry with Swindon Town, known as the A420 Derby.
Both Plymouth and Oxford have had periods of success in English football, with Oxford winning the Football League Cup in 1986 and Plymouth reaching the League Cup semi-finals in 1965.