Caracas FC has participated in the Copa Libertadores numerous times, with their best performance being reaching the quarterfinals in 2009.
Club Atletico Penarol is one of the most successful clubs in Copa Libertadores history, having won the tournament five times.
The two clubs have faced each other twice in Copa Libertadores history, with each team winning one match.
The most recent meeting between Caracas FC and Club Atletico Penarol in Copa Libertadores was in the group stage of the 2020 edition, with Penarol winning 2-1.