Northampton Town's home stadium is Sixfields Stadium with a capacity of 7,798, while Leyton Orient's home stadium is Brisbane Road with a capacity of 9,271.
The two teams have a historic rivalry dating back to their early encounters in the lower divisions of English football.
Northampton Town has won the League Two title twice, in the 1962-63 and 2015-16 seasons, while Leyton Orient has won the same title once in the 1969-70 season.
Leyton Orient has been in League One for longer periods compared to Northampton Town, with their most recent promotion to the league in the 2019-20 season.
In their most recent head-to-head matches in League One, Northampton Town has recorded more victories, with Leyton Orient struggling to secure wins.