TNS (The New Saints) is a Welsh professional football club based in Oswestry, Shropshire, England. They currently play in the Cymru Premier, the top tier of Welsh football.
FK Panevezys is a Lithuanian professional football club based in Panevezys. They compete in the A Lyga, the top tier of Lithuanian football.
TNS qualified for the 2021-2022 Europa Conference League by finishing second in the Cymru Premier during the previous season.
FK Panevezys gained entry to the 2021-2022 Europa Conference League by finishing third in the A Lyga and winning the Lithuanian Football Cup.
This will be TNS's first appearance in the group stage of a UEFA competition, making history for the Welsh club.
FK Panevezys has experience in European competition, having previously competed in the UEFA Europa League qualifiers.